In the bone matrix, the content of collagen is very high. It (collagen fibers) is woven into a net, which is inlaid with proteoglycans and moisture, and also includes a small amount of minerals and fats, because this net locks in moisture and proteoglycans, giving cartilage elasticity.

In the study of active peptides, scientists found that active peptides, as a low molecular weight, can bind a large amount of metal ions, have unique properties, and the active peptides are particularly effective against rheumatism and bone diseases. The mechanism is as follows.

1. During rheumatism and rheumatoid inflammation, collagen fibers are affected by the activity of lysine oxidase. This enzyme contains metal copper. The active peptide can be combined with copper and excreted from the body, reducing the activity of the enzyme, thereby reducing the hyperplasia of the synovial membrane in the joint cavity. 

2.  Active peptides can effectively remove oxygen free radicals generated in the inflammatory reaction, protect adjacent normal tissues, cells are not damaged, and maintain the normal viscosity of the synovial fluid in the joint cavity.

3. Collagen peptides can promote the repair of bone and joint trauma. Active peptides have a two-way regulatory effect on patients with osteoporosis. One is to promote the number of osteocytes and improve the relative imbalance between osteoblasts and osteoclasts in middle-aged and elderly people. The other is the mass of osteocytes, promotes binding with calcium, strengthens bone calcification and bone formation.

4. Fish collagen peptides can activate the vitality of diseased cells and effectively enhance the body’s immunity. Practice has proved that active peptides have obvious inhibitory effects on rheumatism, rheumatoid and other joint diseases, and are safe and have no side effects.

Collagen is one of the most abundant proteins in animal tissues. Its main function is to provide and maintain the structural integrity of the extracellular matrix, and the extracellular matrix of cartilage and bone is rich in collagen. It is an ideal bioscaffold material for osteochondral tissue engineering, and also provides feasibility for early interventional treatment of large-area cartilage defects. Medical-grade fish collagen is made of marine fish scales and skins. The collagen produced by Hainan Huayan’s patented bio-enzyme directional shearing technology has excellent affinity with human cartilage and can be well repaired.

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